Rabbit Anti-PAR11/PARP11 Polyclonal Antibody
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产品编号
PAV2928
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别名
poly(ADP-ribose) polymerase family member 11, ARTD11, C12orf6, MIB006
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | poly(ADP-ribose) polymerase family member 11, ARTD11, C12orf6, MIB006 |
| Catalog Number | PAV2928 |
| Product Description | Rabbit polyclonal antibody raised against human PARP11 (Protein mono-ADP-ribosyltransferase PARP11). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PARP11 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | DNA损伤修复 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables NAD+ poly-ADP-ribosyltransferase activity and NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Located in nuclear body and nuclear envelope. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human PARP11 protein (UniProt: Q9NR21) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 57097 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈39.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 39.6 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9NR21 |
| Note | Gene ID: 57097; UniProt: Q9NR21; Chromosome: 12p13.32; Predicted MW: 39.6 kDa |
| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (By similarity). Inhibits the type I interferon activated signaling pathway. Mechanistically, mono-ADP-ribosylates beta-TrCP/BTRC to promote IFNAR1 ubiquitination and protect BTRC from ubiquitin-proteasome degradation. Additionally, acts as an antiviral factor by cooperating with PARP12 to suppress Zika virus replication, independent of IFNAR1 regulation or intrinsic PARP enzymatic activity. Instead, facilitates the degradation of viral NS1 and NS3 proteins, potentially disrupting viral replication. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PARP11 Polyclonal Antibody |
| Target | PARP11 |
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