Rabbit Anti-MAGG1/NSMCE3 Polyclonal Antibody
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产品编号
PAV2230
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别名
NSE3 component of SMC5/6 complex, HCA4, LICS, MAGEG1, MAGEL3, NDNL2, NSE3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | NSE3 component of SMC5/6 complex, HCA4, LICS, MAGEG1, MAGEL3, NDNL2, NSE3 |
| Catalog Number | PAV2230 |
| Product Description | Rabbit polyclonal antibody raised against human NSMCE3 (Non-structural maintenance of chromosomes element 3 homolog). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NSMCE3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | DNA损伤修复 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011] |
| Immunogen | This antibody was raised against from part region of human NSMCE3 protein (UniProt: Q96MG7) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 56160 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈34.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 34.3 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q96MG7 |
| Note | Gene ID: 56160; UniProt: Q96MG7; Chromosome: 15q13.1; Predicted MW: 34.3 kDa |
| Function | Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NSMCE3 Polyclonal Antibody |
| Target | NSMCE3 |
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