Rabbit Anti-TTLL3 Polyclonal Antibody
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产品编号
PAV4183
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别名
tubulin tyrosine ligase like 3, HOTTL
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | tubulin tyrosine ligase like 3, HOTTL |
| Catalog Number | PAV4183 |
| Product Description | Rabbit polyclonal antibody raised against human TTLL3 (Tubulin monoglycylase TTLL3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TTLL3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 细胞骨架 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables protein-glycine ligase activity. Predicted to be involved in axoneme assembly; flagellated sperm motility; and spermatogenesis. Predicted to be located in cilium. Predicted to be active in axoneme; microtubule cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human TTLL3 protein (UniProt: Q9Y4R7) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 26140 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈87.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 87.4 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9Y4R7 |
| Note | Gene ID: 26140; UniProt: Q9Y4R7; Chromosome: 3p25.3; Predicted MW: 87.4 kDa |
| Function | Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction (By similarity). Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases (By similarity). Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions (By similarity). Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance (By similarity). Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TTLL3 Polyclonal Antibody |
| Target | TTLL3 |
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