Rabbit Anti-TNNC1 Polyclonal Antibody
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产品编号
PAV4084
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别名
troponin I3, cardiac type, CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | troponin I3, cardiac type, CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI |
| Catalog Number | PAV4084 |
| Product Description | Rabbit polyclonal antibody raised against human TNNI3 (Troponin I, cardiac muscle). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TNNI3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 细胞骨架 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020] |
| Immunogen | This antibody was raised against from part region of human TNNI3 protein (UniProt: P19429) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 7137 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈24.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 24.0 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | P19429 |
| Note | Gene ID: 7137; UniProt: P19429; Chromosome: 19q13.42; Predicted MW: 24.0 kDa |
| Function | Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TNNI3 Polyclonal Antibody |
| Target | TNNI3 |
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