Rabbit Anti-PRKRA Polyclonal Antibody
-
产品编号
PAV3155
-
别名
protein activator of interferon induced protein kinase EIF2AK2, DYT16, HSD14, PACT, RAX
-
目录价格
InquiryRMB
-
规格
- 100ul
产品介绍
| Alias | protein activator of interferon induced protein kinase EIF2AK2, DYT16, HSD14, PACT, RAX |
| Catalog Number | PAV3155 |
| Product Description | Rabbit polyclonal antibody raised against human PRKRA (Interferon-inducible double-stranded RNA-dependent protein kinase activator A). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PRKRA |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 细胞因子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008] |
| Immunogen | This antibody was raised against from part region of human PRKRA protein (UniProt: O75569) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 8575 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈34.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 34.4 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | O75569 |
| Note | Gene ID: 8575; UniProt: O75569; Chromosome: 2q31.2; Predicted MW: 34.4 kDa |
| Function | Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity). May function as regulator of gastric epithelial differentiation (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PRKRA Polyclonal Antibody |
| Target | PRKRA |
- 联系我们
- 电话：400-621-6806
- 手机：13116038708（微信）
- 邮箱：info@kmdbioscience.com
- 地址：天津市武清开发区和畅路6号10号厂房108室
-
销售微信
-
官方公众号
-
400-621-6806 -
3599163699 -
周一至周五 9:00-18:00 -
-
0
-
