Rabbit Anti-PBIP1/CENPU Polyclonal Antibody
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产品编号
PAV2946
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别名
centromere protein U, CENP50, CENPU50, KLIP1, MLF1IP, PBIP1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | centromere protein U, CENP50, CENPU50, KLIP1, MLF1IP, PBIP1 |
| Catalog Number | PAV2946 |
| Product Description | Rabbit polyclonal antibody raised against human CENPU (Centromere protein U). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | CENPU |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 细胞周期 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008] |
| Immunogen | This antibody was raised against from part region of human CENPU protein (UniProt: Q71F23) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 79682 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈47.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 47.5 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q71F23 |
| Note | Gene ID: 79682; UniProt: Q71F23; Chromosome: 4q35.1; Predicted MW: 47.5 kDa |
| Function | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human CENPU Polyclonal Antibody |
| Target | CENPU |
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