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Rabbit Anti-NDE1 Polyclonal Antibody

Rabbit Anti-NDE1 Polyclonal Antibody

Rabbit Anti-NDE1 Polyclonal Antibody

产品编号

PAV2469

别名

nudE neurodevelopment protein 1, HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	nudE neurodevelopment protein 1, HOM-TES-87, LIS4, MHAC, NDE, NUDE, NUDE1
Catalog Number	PAV2469
Product Description	Rabbit polyclonal antibody raised against human NDE1 (Nuclear distribution protein nudE homolog 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	NDE1
Species	Human, Rat, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	细胞周期
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Immunogen	This antibody was raised against from part region of human NDE1 protein (UniProt: Q9NXR1)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	54820
Tag	Unconjugated
Cross-reactivity	Human, Rat, Mouse
Predicted Molecular Weight	≈37.7 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	37.7 kDa
Cross-reactivity	Human, Rat, Mouse
Uniprot ID	Q9NXR1
Note	Gene ID: 54820; UniProt: Q9NXR1; Chromosome: 16p13.11; Predicted MW: 37.7 kDa
Function	Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human NDE1 Polyclonal Antibody
Target	NDE1

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