Rabbit Anti-TRI63/TRIM63 Polyclonal Antibody
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产品编号
PAV4126
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别名
tripartite motif containing 63, CMH31, IRF, MURF1, MURF2, RNF28, SMRZ
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | tripartite motif containing 63, CMH31, IRF, MURF1, MURF2, RNF28, SMRZ |
| Catalog Number | PAV4126 |
| Product Description | Rabbit polyclonal antibody raised against human TRIM63 (E3 ubiquitin-protein ligase TRIM63). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TRIM63 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012] |
| Immunogen | This antibody was raised against from part region of human TRIM63 protein (UniProt: Q969Q1) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 84676 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈40.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 40.2 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q969Q1 |
| Note | Gene ID: 84676; UniProt: Q969Q1; Chromosome: 1p36.11; Predicted MW: 40.2 kDa |
| Function | E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TRIM63 Polyclonal Antibody |
| Target | TRIM63 |
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