Rabbit Anti-TRI50/TRIM50 Polyclonal Antibody
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产品编号
PAV4124
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别名
tripartite motif containing 50, TRIM50A
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | tripartite motif containing 50, TRIM50A |
| Catalog Number | PAV4124 |
| Product Description | Rabbit polyclonal antibody raised against human TRIM50 (E3 ubiquitin-protein ligase TRIM50). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TRIM50 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables identical protein binding activity. Predicted to be involved in innate immune response. Predicted to act upstream of or within regulation of establishment of protein localization. Predicted to be located in aggresome. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human TRIM50 protein (UniProt: Q86XT4) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 135892 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈54.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 54.7 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q86XT4 |
| Note | Gene ID: 135892; UniProt: Q86XT4; Chromosome: 7q11.23; Predicted MW: 54.7 kDa |
| Function | E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TRIM50 Polyclonal Antibody |
| Target | TRIM50 |
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