Rabbit Anti-TRI23/TRIM23 Polyclonal Antibody
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产品编号
PAV4119
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别名
tripartite motif containing 23, ARD1, ARFD1, RNF46
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | tripartite motif containing 23, ARD1, ARFD1, RNF46 |
| Catalog Number | PAV4119 |
| Product Description | Rabbit polyclonal antibody raised against human TRIM23 (E3 ubiquitin-protein ligase TRIM23). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TRIM23 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human TRIM23 protein (UniProt: P36406) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 373 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈64.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 64.1 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P36406 |
| Note | Gene ID: 373; UniProt: P36406; Chromosome: 5q12.3; Predicted MW: 64.1 kDa |
| Function | E3 ubiquitin ligase that harbors GTPase activity encoded by the C-terminal ARF domain. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes. Catalyzes 'Lys-63'-linked polyubiquitination of HAX1 that triggers its liquid-liquid phase separation (LLPS) and contributes to P-bodies assembly induced by energy stress.; FUNCTION: (Microbial infection) Mediates TRAF6 auto-ubiquitination in the presence of human cytomegalovirus protein UL144, resulting in the virally controlled activation of NF-kappa-B stimulation at early times of HCMV infection. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TRIM23 Polyclonal Antibody |
| Target | TRIM23 |
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