Rabbit Anti-TOPRS/TOPORS Polyclonal Antibody
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产品编号
PAV4097
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别名
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase, LUN, P53BP3, RP31, TP53BPL
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase, LUN, P53BP3, RP31, TP53BPL |
| Catalog Number | PAV4097 |
| Product Description | Rabbit polyclonal antibody raised against human TOPORS (E3 ubiquitin-protein ligase Topors). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TOPORS |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010] |
| Immunogen | This antibody was raised against from part region of human TOPORS protein (UniProt: Q9NS56) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 10210 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈119.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 119.2 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9NS56 |
| Note | Gene ID: 10210; UniProt: Q9NS56; Chromosome: 9p21.1; Predicted MW: 119.2 kDa |
| Function | Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TOPORS Polyclonal Antibody |
| Target | TOPORS |
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