Rabbit Anti-SPSB3 Polyclonal Antibody
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产品编号
PAV3800
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别名
splA/ryanodine receptor domain and SOCS box containing 3, C16orf31, SSB3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | splA/ryanodine receptor domain and SOCS box containing 3, C16orf31, SSB3 |
| Catalog Number | PAV3800 |
| Product Description | Rabbit polyclonal antibody raised against human SPSB3 (SPRY domain-containing SOCS box protein 3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SPSB3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including negative regulation of cGAS/STING signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein K48-linked ubiquitination. Part of Cul5-RING ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human SPSB3 protein (UniProt: Q6PJ21) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 90864 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈39.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 39.4 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q6PJ21 |
| Note | Gene ID: 90864; UniProt: Q6PJ21; Chromosome: 16p13.3; Predicted MW: 39.4 kDa |
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SPSB3 Polyclonal Antibody |
| Target | SPSB3 |
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