Rabbit Anti-RN183/RNF183 Polyclonal Antibody
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产品编号
PAV3418
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别名
ring finger protein 183
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | ring finger protein 183 |
| Catalog Number | PAV3418 |
| Product Description | Rabbit polyclonal antibody raised against human RNF183 (E3 ubiquitin-protein ligase RNF183). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RNF183 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables ubiquitin protein ligase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human RNF183 protein (UniProt: Q96D59) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 138065 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈21.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 21.6 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q96D59 |
| Note | Gene ID: 138065; UniProt: Q96D59; Chromosome: 9q32; Predicted MW: 21.6 kDa |
| Function | Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling. Mediates the ubiquitination and subsequent lysosomal degradation of ATP1B1 (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RNF183 Polyclonal Antibody |
| Target | RNF183 |
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