Rabbit Anti-PSME1 Polyclonal Antibody
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产品编号
PAV3188
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别名
proteasome activator subunit 1, HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | proteasome activator subunit 1, HEL-S-129m, IFI5111, PA28A, PA28alpha, REGalpha |
| Catalog Number | PAV3188 |
| Product Description | Rabbit polyclonal antibody raised against human PSME1 (Proteasome activator complex subunit 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PSME1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| Immunogen | This antibody was raised against from part region of human PSME1 protein (UniProt: Q06323) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 5720 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈28.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 28.7 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q06323 |
| Note | Gene ID: 5720; UniProt: Q06323; Chromosome: 14q12; Predicted MW: 28.7 kDa |
| Function | Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PSME1 Polyclonal Antibody |
| Target | PSME1 |
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