Rabbit Anti-PACRG Polyclonal Antibody
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产品编号
PAV2914
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别名
parkin coregulated, BUG21, GLUP, HAK005771, PACRG2.1, PARK2CRG, pf12
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | parkin coregulated, BUG21, GLUP, HAK005771, PACRG2.1, PARK2CRG, pf12 |
| Catalog Number | PAV2914 |
| Product Description | Rabbit polyclonal antibody raised against human PACRG (Parkin coregulated gene protein). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PACRG |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human PACRG protein (UniProt: Q96M98) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 135138 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈33.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 33.3 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q96M98 |
| Note | Gene ID: 135138; UniProt: Q96M98; Chromosome: 6q26; Predicted MW: 33.3 kDa |
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PACRG Polyclonal Antibody |
| Target | PACRG |
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