Rabbit Anti-MUL1 Polyclonal Antibody
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产品编号
PAV2396
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别名
mitochondrial E3 ubiquitin protein ligase 1, C1orf166, GIDE, MAPL, MULAN, RNF218
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | mitochondrial E3 ubiquitin protein ligase 1, C1orf166, GIDE, MAPL, MULAN, RNF218 |
| Catalog Number | PAV2396 |
| Product Description | Rabbit polyclonal antibody raised against human MUL1 (Mitochondrial ubiquitin ligase activator of NFKB 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MUL1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including cellular response to exogenous dsRNA; negative regulation of defense response; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrial outer membrane; neuronal cell body; and peroxisome. Part of TOM complex. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human MUL1 protein (UniProt: Q969V5) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 79594 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈39.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 39.8 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q969V5 |
| Note | Gene ID: 79594; UniProt: Q969V5; Chromosome: 1p36.12; Predicted MW: 39.8 kDa |
| Function | E3 ubiquitin-protein ligase activity, which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteasomal degradation. Mediates polyubiquitination of cytoplasmic p53/TP53 at 'Lys-24' which targets TP53 for proteasomal degradation, thus reducing TP53 levels in the cytoplasm and mitochondrion. Also involved in antiviral immunity by mediating 'Lys-63'-linked ubiquitination of STING1, promoting production of type I interferon (IFN-alpha and IFN-beta), whitout activating STING1-dependent NF-kappa-B signaling. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Involved in the modulation of innate immune defense against viruses by inhibiting RIGI-dependent antiviral response. Can mediate RIGI sumoylation and disrupt its polyubiquitination. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MUL1 Polyclonal Antibody |
| Target | MUL1 |
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