Rabbit Anti-MARH9/MARCHF9 Polyclonal Antibody
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产品编号
PAV2246
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别名
membrane associated ring-CH-type finger 9, MARCH-IX, MARCH9, RNF179
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | membrane associated ring-CH-type finger 9, MARCH-IX, MARCH9, RNF179 |
| Catalog Number | PAV2246 |
| Product Description | Rabbit polyclonal antibody raised against human MARCHF9 (E3 ubiquitin-protein ligase MARCHF9). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MARCHF9 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010] |
| Immunogen | This antibody was raised against from part region of human MARCHF9 protein (UniProt: Q86YJ5) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 92979 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈37.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 37.8 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q86YJ5 |
| Note | Gene ID: 92979; UniProt: Q86YJ5; Chromosome: 12q14.1; Predicted MW: 37.8 kDa |
| Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MARCHF9 Polyclonal Antibody |
| Target | MARCHF9 |
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