Rabbit Anti-MARH6/MARCHF6 Polyclonal Antibody
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产品编号
PAV2243
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别名
membrane associated ring-CH-type finger 6, DOA10, FAME3, FCMTE3, MARCH-VI, MARCH6, RNF176, TEB4
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | membrane associated ring-CH-type finger 6, DOA10, FAME3, FCMTE3, MARCH-VI, MARCH6, RNF176, TEB4 |
| Catalog Number | PAV2243 |
| Product Description | Rabbit polyclonal antibody raised against human MARCHF6 (E3 ubiquitin-protein ligase MARCHF6). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MARCHF6 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 自噬与泛素化 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012] |
| Immunogen | This antibody was raised against from part region of human MARCHF6 protein (UniProt: O60337) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 10299 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈102.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 102.5 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | O60337 |
| Note | Gene ID: 10299; UniProt: O60337; Chromosome: 5p15.2; Predicted MW: 102.5 kDa |
| Function | Endoplasmic reticulum membrane-associated E3 ubiquitin ligase that plays a critical role in mitigating endoplasmic reticulum stress, the regulation of cholesterol and lipid homeostasis, and ferroptosis. Acts as a pivotal component of both the Ac/N-degron pathway (targeting the N-terminal acetyl group of substrates) and the ER-associated protein degradation-cytosol (ERAD-C) pathway (targeting misfolded substrates). For instance, mediates the degradation of Ac/N-degron-bearing proteins such as the G protein regulator RGS2 and the lipid droplet protein PLIN2. Suppresses endoplasmic reticulum stress and ferroptosis through cytosolic POMC degradation (By similarity). Prevents ferroptosis by acting as a NADPH sensor during lipid peroxidation through its C-terminal regulatory region. Facilitates also the degradation of selected endoplasmic reticulum proteins by associating with signal peptide peptidase for the turnover of endogenous tail-anchored proteins. Promotes ubiquitination of DIO2, leading to its degradation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MARCHF6 Polyclonal Antibody |
| Target | MARCHF6 |
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