Rabbit Anti-SIVA/SIVA1 Polyclonal Antibody
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产品编号
PAV3687
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别名
SIVA1 apoptosis inducing factor, CD27BP, SIVA, Siva-1, Siva-2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SIVA1 apoptosis inducing factor, CD27BP, SIVA, Siva-1, Siva-2 |
| Catalog Number | PAV3687 |
| Product Description | Rabbit polyclonal antibody raised against human SIVA1 (Apoptosis regulatory protein Siva). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SIVA1 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 凋亡 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes an E3 ubiquitin ligase that regulates cell cycle progression, cell proliferation and apoptosis. The N-terminus of this protein binds to the cytoplasmic tail of the CD27 antigen, a member of the tumor necrosis factor receptor (TNFR) superfamily. In response to UV radiation-induced DNA damage, this protein has been shown to mediate the ubiquitination of proliferating cell nuclear antigen (PCNA), an important step in translesion DNA synthesis. [provided by RefSeq, Sep 2018] |
| Immunogen | This antibody was raised against from part region of human SIVA1 protein (UniProt: O15304) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 10572 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈18.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 18.7 kDa |
| Cross-reactivity | Human |
| Uniprot ID | O15304 |
| Note | Gene ID: 10572; UniProt: O15304; Chromosome: 14q32.33; Predicted MW: 18.7 kDa |
| Function | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SIVA1 Polyclonal Antibody |
| Target | SIVA1 |
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