Rabbit Anti-PJVK Polyclonal Antibody
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产品编号
PAV3051
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别名
pejvakin, DFNB59
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | pejvakin, DFNB59 |
| Catalog Number | PAV3051 |
| Product Description | Rabbit polyclonal antibody raised against human PJVK (Pejvakin). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PJVK |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他信号分子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59). [provided by RefSeq, Dec 2008] |
| Immunogen | This antibody was raised against from part region of human PJVK protein (UniProt: Q0ZLH3) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 494513 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈39.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 39.9 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q0ZLH3 |
| Note | Gene ID: 494513; UniProt: Q0ZLH3; Chromosome: 2q31.2; Predicted MW: 39.9 kDa |
| Function | Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PJVK Polyclonal Antibody |
| Target | PJVK |
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