Rabbit Anti-Polyclonal AntibodyP4/PABPC4 Polyclonal Antibody
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产品编号
PAV2910
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别名
poly(A) binding protein cytoplasmic 4, APP-1, APP1, PABP4, iPABP
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | poly(A) binding protein cytoplasmic 4, APP-1, APP1, PABP4, iPABP |
| Catalog Number | PAV2910 |
| Product Description | Rabbit polyclonal antibody raised against human PABPC4 (Polyadenylate-binding protein 4-binding protein 4)-binding protein)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PABPC4 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他信号分子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. This protein has also been found to interact with coronavirus nucleocapsid proteins and is thought to inhibit coronavirus replication. [provided by RefSeq, Nov 2021] |
| Immunogen | This antibody was raised against from part region of human PABPC4 protein (UniProt: Q13310) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 8761 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈70.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 70.8 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q13310 |
| Note | Gene ID: 8761; UniProt: Q13310; Chromosome: 1p34.3; Predicted MW: 70.8 kDa |
| Function | Binds the poly(A) tail of mRNA. Binds to SMIM26 mRNA and plays a role in its post-transcriptional regulation. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PABPC4 Polyclonal Antibody |
| Target | PABPC4 |
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