Rabbit Anti-NPRL3 Polyclonal Antibody
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产品编号
PAV2576
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别名
NPR3 like, GATOR1 complex subunit, C16orf35, CGTHBA, FFEVF3, HS-40, MARE, NPR3, RMD11
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | NPR3 like, GATOR1 complex subunit, C16orf35, CGTHBA, FFEVF3, HS-40, MARE, NPR3, RMD11 |
| Catalog Number | PAV2576 |
| Product Description | Rabbit polyclonal antibody raised against human NPRL3 (GATOR1 complex protein NPRL3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NPRL3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 其他信号分子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Predicted to enable GTPase activator activity. Involved in cellular response to amino acid starvation and negative regulation of TORC1 signaling. Part of GATOR1 complex. Is active in lysosomal membrane. Implicated in familial focal epilepsy with variable foci 3. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human NPRL3 protein (UniProt: Q12980) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 8131 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈63.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 63.6 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q12980 |
| Note | Gene ID: 8131; UniProt: Q12980; Chromosome: 16p13.3; Predicted MW: 63.6 kDa |
| Function | As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the mTORC1 pathway. In response to amino acid depletion, the GATOR1 complex has GTPase activating protein (GAP) activity and strongly increases GTP hydrolysis by RagA/RRAGA (or RagB/RRAGB) within heterodimeric Rag complexes, thereby turning them into their inactive GDP-bound form, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. In the presence of abundant amino acids, the GATOR1 complex is negatively regulated by GATOR2, the other GATOR subcomplex, in this amino acid-sensing branch of the TORC1 pathway. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NPRL3 Polyclonal Antibody |
| Target | NPRL3 |
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