Human CD137 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD137 Protein, His Tag

Human CD137 Protein, His Tag

产品编号

KMP2423

别名

肿瘤坏死因子超家族受体9, CD137, ILA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子超家族受体9, CD137, ILA
Catalog Number	KMP2423
Product Description	The Human CD137 Protein(KMP2423) is produced in HEK293 Cells and the target gene encoding Leu24-Gln186 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD137
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer(NK) cells, follicular dendritic cells(FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L(4-1BBL).
SDS-PAGE
Predicted Molecular Weight	18.11 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q12933
References	1.Genes Dev. 13:1297-1308 (1999) 2.Mol. Cell. Biol. 22:737-749 (2002) 3.Nature 416:345-347 (2002) 4.Nature 424:793-796 (2003) 5. Mol. Cell. Biol. 24:4502-4512 (2004) 6.J. Biol. Chem. 279:55855-55865 (2004) 7.Cell Rep. 3:724-733 (2013)
Function	Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis (PubMed:22212761). Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE

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