Human CD137 Protein, Fc Tag, His Tag_天津卡梅德科技发展有限公司

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Human CD137 Protein, Fc Tag, His Tag

Human CD137 Protein, Fc Tag, His Tag

产品编号

KMP2372

别名

肿瘤坏死因子超家族受体9, CD137, ILA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子超家族受体9, CD137, ILA
Catalog Number	KMP2372
Product Description	The Human CD137 Protein(KMP2372) is produced in HEK293 Cells and the target gene encoding Leu24-Gln186 is expressed with a Fc, 6His tag at the C-terminus.
Molecular Name	CD137
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. It is absent from naive T cells, but upregulated and continually expressed following T cell activation. It is a receptor for TNFSF9/4-1BBL, and possibly active during T cell activation.
SDS-PAGE
Predicted Molecular Weight	18.11 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q13077
References	1.FEBS Lett. 468:129-133 (2000) 2.Eur. J. Immunol. 36:199-206 (2006) 3.Genes Cells 13:509-520 (2008) 4.Oncogene 28:1769-1781 (2009) 5.Mol. Immunol. 46:3278-3282 (2009) 6.Mol. Cell 38:101-113 (2010)
Function	Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.

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