Human CD33L3 Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD33L3 Protein, His Tag

Human CD33L3 Protein, His Tag

产品编号

KMP2361

别名

唾液酸结合免疫球蛋白样凝集素-15, Sialic acid-binding Ig-like lectin 15, Siglec-15

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	唾液酸结合免疫球蛋白样凝集素-15, Sialic acid-binding Ig-like lectin 15, Siglec-15
Catalog Number	KMP2361
Product Description	The Human CD33L3 Protein(KMP2361) is produced in HEK293 Cells and the target gene encoding Phe20-Thr263 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD33L3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 150mM Nacl, 0.3% Chaps, 5% Trehalose, pH7.4
Background	Human Siglec-15 is a transmembrane glycoprotein in the Siglec family. Siglecs are type I transmembrane proteins where the NH3+-terminus is in the extracellular space and the COO--terminus is cytosolic. Each Siglec contains an N-terminal V-type immunoglobulin domain(Ig domain) which acts as the binding receptor for sialic acid. These lectins are placed into the group of I-type lectins because the lectin domain is an immunoglobulin fold. All Siglecs are extended from the cell surface by C2-type Ig domains which have no binding activity. Siglecs differ in the number of these C2-type domains. Human Siglec-15 consists of a 244 amino acid(aa) extracellular domain(ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 function is important for osteoclast formation and TRANCE/RANK Ligand signaling in osteoclasts
SDS-PAGE
Predicted Molecular Weight	27.39 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9BZZ2
References	1.Mol. Microbiol. 49:1213-1225 (2003) 2.Cell Res. 25:1121-1136 (2015) 3.PLoS Pathog. 13:e1006181-e1006181 (2017) 4.J. Extracell. Vesicles 10:e12046-e12046 (2021) 5.Cell. Mol. Immunol. 18:2676-2678 (2021) 6.Nat. Microbiol. 4:1558-1570 (2019)
Function	Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response (PubMed:12940982, PubMed:33489013). Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs)(PubMed:28129379). In turn, enhances macrophage-to-T-cell transmission of several viruses including HIV-1 or SARS-CoV-2 (PubMed:28129379, PubMed:34782760). Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid (PubMed:12940982). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination (PubMed:26358190). (Microbial infection) Facilitates viral cytoplasmic entry into activated dendritic cells via recognition of sialylated gangliosides pesent on viral membrane.

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