Mouse CD226 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD226 Protein, His Tag

Mouse CD226 Protein, His Tag

产品编号

KMP2322

别名

白细胞分化抗原, CD226 antigen, CD226

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞分化抗原, CD226 antigen, CD226
Catalog Number	KMP2322
Product Description	The Mouse CD226 Protein(KMP2322) is produced in HEK293 Cells and the target gene encoding Glu19-Pro254 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD226
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mouse DNAX accessory molecule-1(DNAM-1) is a type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. As an activating receptor, it interacts with the ligands CD155 and CD112, and activates natural killer(NK) cells via its immu-noreceptor tyrosine-based activatory motif(ITAM). Mature mouse DNAM-1 has extracellular domain(ECD) that contains two Ig-like C2-set domains, and possesses a cytoplasmic region that contains motifs for binding PDZ domains. DNAM-1 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR and Nectin-2/CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, induces dendritic cell maturation, initiates megakaryocyte and activated platelet adhesion to vascular endothelial cells, and stimulates monocyte extravasation- Conversely, it inhibits the formation of osteoclasts. Platelet-endothelium interactions that are mediated by DNAM-1 enable the metastasis of tumor cells to the lung.
SDS-PAGE
Predicted Molecular Weight	27.61 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q8K4F0
Function	Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.

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