Human CD137 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Human CD137 Protein, Fc Tag

Human CD137 Protein, Fc Tag

产品编号

KMP2300

别名

肿瘤坏死因子超家族受体9, CD137, ILA

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子超家族受体9, CD137, ILA
Catalog Number	KMP2300
Product Description	The Human CD137 Protein(KMP2300) is produced in HEK293 Cells and the target gene encoding Leu24-Gln186 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD137
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer(NK) cells, follicular dendritic cells(FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L(4-1BBL).
SDS-PAGE
Predicted Molecular Weight	17.37 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q07011
References	J. Allergy Clin. Immunol. 144:574-583 (2019)
Function	Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8+ T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).

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