Mouse ILT3 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse ILT3 Protein, Fc Tag

Mouse ILT3 Protein, Fc Tag

产品编号

KMP2269

别名

白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, ILT3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, ILT3
Catalog Number	KMP2269
Product Description	The Mouse ILT3 Protein(KMP2269) is produced in HEK293 Cells and the target gene encoding Gly24-Lys238 is expressed with a Fc tag at the C-terminus.
Molecular Name	ILT3
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	50mM Tris-HCl, 100mM Glycine, pH7.5
Background	Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 is expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.
SDS-PAGE
Predicted Molecular Weight	23.65 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q64281
References	1.J. Biol. Chem. 274:5791-5796 (1999) 2.Nat. Immunol. 2:436-442 (2001) 3.J. Exp. Med. 194:227-234 (2001) 4.J. Immunol. 170:4095-4101 (2003) 5.Eur. J. Immunol. 33:2262-2268 (2003) 6.J. Immunol. 193:635-644 (2014) 7.Int. Immunol. 33:447-458 (2021) 8.J. Immunol. 158:9-12 (1997)
Function	Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:8855262, PubMed:10026201, PubMed:11457897, PubMed:11323698). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169).

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