Human ANGPTL4 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ANGPTL4 Protein, His Tag

Human ANGPTL4 Protein, His Tag

产品编号

KMP2268

别名

血管生成素样蛋白4, Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, ANGPTL4

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	血管生成素样蛋白4, Angiopoietin-related protein 4, 425O18-1, Angiopoietin-like protein 4, ANGPTL4
Catalog Number	KMP2268
Product Description	The Human ANGPTL4 Protein(KMP2268) is produced in HEK293 Cells and the target gene encoding Pro166-Ser406 is expressed with a 6His tag at the N-terminus.
Molecular Name	ANGPTL4
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Angiopoietin-related protein 4(ANGPTL4)is a secreted protein and contains 1 fibrinogen C-terminal domain. The protein may act as a regulator of angiogenesis and modulate tumorigenesis. It inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 may exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity(By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix(ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
SDS-PAGE
Predicted Molecular Weight	27.91 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q9BY76
References	1.Cancer Res. 63:6651-6657 (2003) 2.Circ. Res. 99:1207-1215 (2006) 3.J. Biol. Chem. 284:13213-13222 (2009) 4.J. Biol. Chem. 286:15747-15756 (2011) 5.Elife 5:0-0 (2016) 6.Proc. Natl. Acad. Sci. U.S.A. 115:E6020-E6029 (2018) 7.Nat. Commun. 9:2252-2252 (2018)
Function	1.Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. 2.May also play a role in regulating glucose homeostasis and insulin sensitivity (Probable). Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. 3.Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and focal adhesions in endothelial cells that have adhered to ANGPTL4-containing ECM (in vitro). 4.Depending on context, may modulate tumor-related angiogenesis (By similarity).

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