Human CD70 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD70 Protein, mFc Tag

Human CD70 Protein, mFc Tag

产品编号

KMP2255

别名

肿瘤坏死因子配体超家族成员 7, Tumor necrosis factor ligand superfamily member 7, CD70

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子配体超家族成员 7, Tumor necrosis factor ligand superfamily member 7, CD70
Catalog Number	KMP2255
Product Description	The Human CD70 Protein(KMP2255) is produced in HEK293 Cells and the target gene encoding Gln45-Pro193 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD70
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD27 Ligand(CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor(TNF) ligand family.Human CD27 Ligand extracellular region is 64% aa identical to mouse and rat CD27 Ligand extracellular regions. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.
SDS-PAGE
Predicted Molecular Weight	16.44 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P32970
References	1.J. Exp. Med. 214:73-89 (2017) 2.J. Exp. Med. 214:91-106 (2017) 3.J. Immunol. 152:1756-1761 (1994)
Function	Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

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