Human CD272 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD272 Protein, mFc Tag

Human CD272 Protein, mFc Tag

产品编号

KMP2252

别名

B和T淋巴细胞衰减因子, B- and T-Lymphocyte Attenuator, CD272

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	B和T淋巴细胞衰减因子, B- and T-Lymphocyte Attenuator, CD272
Catalog Number	KMP2252
Product Description	The Human CD272 Protein(KMP2252) is produced in HEK293 Cells and the target gene encoding Lys31-Leu150 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD272
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	B- and T-Lymphocyte Attenuator(BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type(immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors(TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor(receptor) superfamily, member 14(TNFRSF14), also known as herpes virus entry mediator(HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
SDS-PAGE
Predicted Molecular Weight	13.2 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q7Z6A9
References	1.Nat. Immunol. 4:670-679 (2003) 2.Biochem. Biophys. Res. Commun. 312:1236-1243 (2003) 3.Nat. Immunol. 6:90-98 (2005) 4.Nat. Immunol. 9:176-185 (2008) 5.J. Immunol. 183:7286-7296 (2009)
Function	1.Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. 2.May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. 3.In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells.

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