Human CD223 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human CD223 Protein, His Tag, Avi Tag

Human CD223 Protein, His Tag, Avi Tag

产品编号

KMP2247

别名

淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	淋巴细胞活化基因3, Lymphocyte activation gene 3 protein, LAG3
Catalog Number	KMP2247
Product Description	The Human CD233 Protein(KMP2247) is produced in HEK293 Cells and the target gene encoding Leu23-Leu450 is expressed with a 6His, Avi tag at the C-terminus.
Molecular Name	CD223
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Human Lymphocyte activation gene 3 protein( LAG3) is a member of immunoglobulin(Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. LAG3 is involved in lymphocyte activation and can bind to HLA class-II antigens. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells and acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling. It can lead to increased antigen-specific T-cell responses in vivo. LAG-3 has higher affinity to MHC class II than CD4.
SDS-PAGE
Predicted Molecular Weight	47.02 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P18627
References	1.J. Immunol. 184:6545-6551 (2010) 2.Eur. J. Immunol. 24:3216-3221 (1994) 3.Eur. J. Immunol. 26:1180-1186 (1996)
Function	Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Delivers inhibitory signals upon binding to ligands, such as FGL1 (By similarity). FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function (By similarity). Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation (By similarity). May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1 (By similarity). Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8+ and CD4+ T-cells (PubMed:7805750, PubMed:8647185, PubMed:20421648). Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function (By similarity). Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation (By similarity). Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear (PubMed:8647185).

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