Human CD137L Protein, His Tag_天津卡梅德科技发展有限公司

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Human CD137L Protein, His Tag

Human CD137L Protein, His Tag

产品编号

KMP2413

别名

肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP2413
Alias	肿瘤坏死因子配体超家族成员 9, CD137L, TNFSF9
Size	50ug, 100ug, 200ug
Product Description	The Human CD137L Protein(KMP2413) is produced in E.coli and the target gene encoding Arg71-Glu254 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD137L
Product Introduction	CD137L（4-1BBL）：CD137的天然配体，通过跨膜形式参与免疫细胞活化和功能调节。
Molecular Weight	20.9 kDa
Expression System	E. coli
Species	Human
Purity	>95%
SDS-PAGE
Purification	Affinity Purification
Uniprot ID	P41273
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM TrisHCl, 150mM NaCl, pH7.4
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Background	Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1BBL is a 254 amino acids cytokine that is expressed in brain, placenta, lung, skeletal muscle and kidney. TNFSF9 has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine may have a role in activation-induced cell death(AICD) and cognate interactions between T-cells and B-cells/macrophages. It has also been shown to be required for the optimal CD8 responses in CD8 T cells, and is thought to be involved in T cell-tumor cell interaction.
Endotoxin	<1.0 EU/ug determined by the LAL method
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。

FAQ

如何提高重组蛋白的可溶性表达？

可优化表达条件（如降低诱导温度、调整IPTG浓度）、使用促溶标签（如SUMO、GST）、共表达分子伴侣，或尝试不同宿主系统（如哺乳动物细胞或昆虫细胞）以提高可溶性蛋白产量。
重组蛋白纯化常用的方法有哪些？

常用的纯化方法包括亲和层析（如His-Tag、GST-Tag）、离子交换层析、疏水相互作用层析（HIC）和凝胶过滤层析。具体方法取决于蛋白特性和标签类型。

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